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KMID : 0358420090520030372
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Korean Journal of Obstetrics and Gynecology
2009 Volume.52 No. 3 p.372 ~ p.376
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A case of microinvasive Paget` disease of the vulva: Treatment of positive resection margin with topical 5-FU cream application
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Kang Ho-Jeong
Kim Sung-Yob
Son Young-Soo
Park Chul-Min
Shim Soon-Sup
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Abstract
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Extramammary Paget’s disease of the vulva is a rare lesion that accounts for 1~2% of vulvar neoplasms. Paget’s disease often has a microscopic extension beyond the gross lesion and shows a multifocal distribution. Positive resection margin is common. We applied 5-FU cream on the lesion who had a positive resection margin. There was no residual lesion on multiple punch biopsies after 5-FU cream treatment three months later. And there has been no evidence of disease recurrence in the 12-month follow-up period. We experienced a case of effective treatment with 5-FU cream in microinvasive Paget’s disease of the vulva with positive resection margin. We present it with a brief review of literatures.
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KEYWORD
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Extramammary Paget`s disease of the vulva, 5-fluorouracil, 5-FU
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